Aptamer: A Novel Therapeutic Oligonucleotide
Nrupa Patel and Sandipkumar Patel Received: June 10, 2017 | Published: July 11, 2017 Citation: Patel N, Patel S (2017) Aptamer: A Novel Therapeutic Oligonucleotide. J Nanomed Res 5(6): 00134. DOI: 10.15406/jnmr.2017.05.00134 Abstract: The aptamer is an oligonucleotide which is a short version of biological nucleic acids (such as DNA and RNA) with defined sequence of nucleotides. Based on the complexity of molecule, the aptamers lies in-between protein molecules and small chemical molecules. Aptamers have high specificity and affinity towards target proteins. They are screened from random sequences of oligonucleotides based on the highest affinity for target proteins using the SELEX (Systematic Evolution of Ligands by Exponential Enrichment). Researchers have discovered various applications of aptamers that are ready to replace the therapeutic use of biological proteins (such as antibodies) that have complexity in manufacturing and characterization. The present review des